@article{Dzhumaeva_Tabarov_Fayzulloev_2020, title={Combination of the therapy of the anticoagulants and Tivortin in patients with cardiac ishemia at COVID-19}, url={https://infusion-chemotherapy.com/index.php/journal/article/view/100}, DOI={10.32902/2663-0338-2020-3.1-76}, abstractNote={<p><strong>Background.</strong> Аn L-arginine is a conditionally essential amino acid. The daily average requirement is 4.2 mg. The L-arginine exhibits angioprotective properties, regulates proliferation and apoptosis, oxidative processes, blocks platelet aggregation and has a fibrinolytic effect ‒ antithrombotic (prevents the adhesion of circulating platelets and leukocytes) for anti-inflammatory effects. The likelihood of developing thrombotic complications in all patients with COVID-19 is very high, such patients are recommended to double dosage of anticoagulants.</p> <p><strong>Objective.</strong> To study the combination of the anticoagulant therapy and the drug Tivortin in patients with coronary artery disease with COVID-19.</p> <p><strong>Materials and methods.</strong> 28 patients with the cardiac ischemia of the exertion stenocardia functional class II-III with COVID-19 were examined. The patients were divided into the main and control groups. One of the groups, in addition to the anticoagulant therapy Clexan 2 times 0.6 mg, have taken the drug Tivortin, manufactured by “Yuria-Pharm” (Ukraine), containing L-arginine (4.2 mg).</p> <p><strong>Results.</strong> The therapy with the use of the nitrate oxide donors in combination with the anticoagulants in the main group showed an increase in exercise tolerance, in the SpO<sub>2</sub> level, i.e., a decrease in hypoxia in the main group compared with the control group.</p> <p><strong>Conclusions.</strong> The addition of Tivortin to the therapy of anticoagulants that inhibit the activity of the blood coagulation system may increase the chances of survival of patients hospitalized with COVID-19.</p&gt;}, number={3.1}, journal={Infusion & Chemotherapy}, author={Dzhumaeva, M.J. and Tabarov, A.I. and Fayzulloev, Kh.T.}, year={2020}, month={Oct.}, pages={91-91} }