Application of the “Trio” pharmacotherapy regimen in patients with chronic arterial insufficiency IIb-III

Abstract

Objective. To evaluate the effectiveness of the “Trio” pharmacotherapy regimen in patients with chronic arterial insufficiency IIb-III.

Materials and methods. 45 patients with a confirmed diagnosis of peripheral arterial occlusive disease of the lower extremities and chronic arterial insufficiency IIb-III were included in the study. All patients were randomly divided into two groups. Patients from experimental group received “Trio” pharmacotherapy (multicomponent isoosmolar solution containing petoxifyllin; multicomponent hyperosmolar solution containing sodium lactate; L-arginine hydrochloridum solution). Patients from comparison group received medical therapy with multicomponent hyperosmolar solution containing sodium lactate and L-arginine hydrochloridum solution.

Results and discussion. The duration of hospital stay was significantly shorter (p<0.01) in the experimental group (7.9±0.97 days) than in the comparison group (9.8±1.63 days). After treatment painless walking distance and peripheral oxygen saturation were significantly greater (p<0.01) in the experimental group (126.25±72.16 m and 90.65±5.07 %) than in the comparison group (54.20±33.59 m and 79.48±6.91 %). At the same time, and intensity of pain was significantly lower (p<0.01) in the experimental group (3.25±1.68 points) than in the comparison group (4,80±1.53 points). The values of the ankle-brachial pressure index were not differing (p<0.05) in both groups (0.49±0.16 and 0.51±0.17 for the experimental group and comparison group, respectively).

Conclusions. “Trio” pharmacotherapy regimen in patients with chronic arterial insufficiency IIb-III allows to improve the basic indicators of the functional state of the microvasculature of the lower extremities.