Inhaled antiseptics and inhaled antiviral non-prescription drugs in the prevention of ARVI, in particular COVID-19: an epidemiological study

  • Yu.I. Feshchenko SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0002-8933-8811
  • M.I. Gumeniuk SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0002-4365-6224
  • М.І. Lynnyk SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0002-0011-7482
  • O.Ya. Dziublyk SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0001-5751-684X
  • M.M. Kuzhko SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0001-6730-9238
  • О.V. Tereshkovych SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0002-7202-295X
  • O.V. Khmel SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”, Kyiv, Ukraine https://orcid.org/0000-0003-4512-2207
  • I.O. Panashchuk SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”, Kyiv, Ukraine
  • M.V. Yashchenko Pharmaxi LLC, Kyiv, Ukraine https://orcid.org/0000-0002-6161-3527
  • О.S. Denysov Association for Intensive Care of Infectious Diseases (INCURE), Kyiv, Ukraine
  • Т.А. Sprynsian Association for Intensive Care of Infectious Diseases (INCURE), Kyiv, Ukraine

Abstract

BACKGROUND. The article presents the results of a continuous, cross-sectional, non-interventional, multicenter retrospective epidemiological study, which included cases of 3443 participants. Questionnaires and rapid test for antibodies to SARS-CoV-2 were used to collect data.

OBJECTIVE. To determine the relationship between the systematic use of additional drugs for the prevention of COVID-19, including inhaled antiseptics and inhaled antiviral drugs, separately and in combination with other drugs, and the risk of developing of coronavirus disease (COVID-19).

RESULTS AND DISCUSSION. 396 participants (11.8 %) took inhaled antiseptics in any period since March 2020, and 410 participants (12.2 %) took inhaled antivirals. A statistically significant protective relationship between episode of COVID-19 when taking inhaled antiseptics and inhaled antiviral drugs (risk ratio 0.901; 95 % confidence interval 0.856-0.948) was determined.

CONCLUSIONS. The use of inhaled antiseptics and inhaled antiviral drugs as additional methods of prevention of COVID-19 has shown a statistically significant effect not only on reducing the risk of COVID-19, but different combinations of inhaled antiseptics or inhaled antiviral drugs with other drug groups as additional methods of preventing COVID-19 had a statistically significant protective relationship with the episode of the disease, with the severity of COVID-19 and with the need for hospitalization.

Keywords: inhaled antiseptics, inhaled antiviral drugs, coronavirus infection, prevention of infectious diseases, non-prescription drugs, epidemiological research.

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Published
2021-12-27
How to Cite
Feshchenko, Y., Gumeniuk, M., LynnykМ., Dziublyk, O., Kuzhko, M., TereshkovychО., Khmel, O., Panashchuk, I., Yashchenko, M., DenysovО., & SprynsianТ. (2021). Inhaled antiseptics and inhaled antiviral non-prescription drugs in the prevention of ARVI, in particular COVID-19: an epidemiological study. Infusion & Chemotherapy, (4), 5-15. https://doi.org/10.32902/2663-0338-2021-4-5-15
Section
ORIGINAL STUDIES

Author Biographies

Yu.I. Feshchenko, SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”, Kyiv, Ukraine

Feshchenko Yurii Ivanovych
Director
Academician of the NAMS of Ukraine, MD, professor.
10, M. Amosova st., Kyiv, 03038, Ukraine.

M.I. Gumeniuk, SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”, Kyiv, Ukraine

Gumeniuk Mykola Ivanovych
Leading researcher of the Department of technologies of treatment of nonspecific lung diseases
MD, professor.
10, M. Amosova st., Kyiv, 03038, Ukraine.

М.І. Lynnyk, SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”, Kyiv, Ukraine

Lynnyk Mykola Ivanovych
Head of the Department of epidemiology and organizational problems of phthisiology
MD
10, M. Amosova st., Kyiv, 03038, Ukraine.

O.Ya. Dziublyk, SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”, Kyiv, Ukraine

Dziublyk Oleksandr Yaroslavovych
Head of the Department of technologies for the treatment of nonspecific lung diseases
MD, professor.
10, M. Amosova st., Kyiv, 03038, Ukraine.

M.M. Kuzhko, SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”, Kyiv, Ukraine

Kuzhko Mykhailo Mykhailovych
Leading researcher of the Department of chemo-resistant tuberculosis
MD, professor.
10, M. Amosova st., Kyiv, 03038, Ukraine.

О.V. Tereshkovych, SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”, Kyiv, Ukraine

Tereshkovych Oleksandr Volodymyrovych
Senior researcher of the Department of thoracic surgery and invasive diagnostic methods
PhD.
10, M. Amosova st., Kyiv, 03038, Ukraine.

O.V. Khmel, SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”, Kyiv, Ukraine

Khmel Oleg Volodymyrovych
Head of the Department of surgical treatment of tuberculosis and nonspecific lung diseases
MD
10, M. Amosova st., Kyiv, 03038, Ukraine.

I.O. Panashchuk, SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”, Kyiv, Ukraine

Panashchuk Ihor Oleksiiovych
Head of the Department of pulmonology and evidence-based medicine
PhD
10, M. Amosova st., Kyiv, 03038, Ukraine.

M.V. Yashchenko, Pharmaxi LLC, Kyiv, Ukraine

Yashchenko Mariia
Head of Biometrics
10A, Akademika Filatova st., Kyiv, 01042, Ukraine.
E-mail: yashchenko@pharmaxi.com.ua

О.S. Denysov, Association for Intensive Care of Infectious Diseases (INCURE), Kyiv, Ukraine

Denysov Oleksii Serhiiovych
Executive director
10, M. Amosova st., Kyiv, 03038, Ukraine.

Т.А. Sprynsian, Association for Intensive Care of Infectious Diseases (INCURE), Kyiv, Ukraine

Sprynsian Tetiana
Vice director / TB
10, M. Amosova st., Kyiv, 03038, Ukraine.

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