Personalized oncology as a global uniting aim of clinical experience, unified protocols and modern technologies on the way to the victory against neoplastic processes
Background. According to the prognoses, by 2025 the global cancer incidence will increase to 24 million cases per year, and mortality – up to 16 million cases. The annual growth rate of tumors number exceeds the growth rate of global population, which justifies the feasibility of improving the diagnosis, treatment and prevention of these diseases.
Objective. Describe the main features of personalized oncology.
Materials and methods. Analysis of regulatory documents and literature sources on this topic.
Results and discussion. In their work Ukrainian oncologists are guided by the domestic documents and the documents of international societies. Personalization of treatment involves taking into account such characteristics of the disease as its stage, morphological affiliation of cells and molecular genetic characteristics of the tumor, as well as such patient characteristics as sex, age, general somatic status, comorbidities, and place of residence. Personalized medicine is a set of methods for diagnosis, treatment and prevention of pathological conditions, based on the individual characteristics of the patient (genetic, epigenetic, transcriptomic, proteomic, metagenomic markers, phenotypic features). For the introduction of personalized medicine into oncology it is necessary to use the molecular genetic profiling of the tumor, to assess the risks with the help of several specialists, to involve the patient in decision-making regarding treatment and diagnostic measures. The main tools for the widespread introduction of personalized medicine include qualified specialists, laboratories of pharmacogenetics and pharmacokinetics, the formation of competencies in health care providers and the development of personalized pharmacy. The main result is the widespread implementation of treatment programs using personalized protocols with targeted delivery of the drug to the appropriate targets, taking into account the state of the body of the particular patient at the specific time.
Conclusions. 1. The incidence of cancer is steadily growing. 2. Personification of treatment involves taking into account the stage of the disease, morphological affiliation of cells and molecular genetic characteristics of the tumor, as well as individual characteristics of the patient. 3. For the introduction of personalized medicine in oncology it is necessary to use molecular genetic profiling of the tumor, to assess the risks with the help of several specialists, to involve the patient in decision-making regarding treatment and diagnostic measures.
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