Features of phagocytic blood activity in patients with MDR-TB on a background of relapse of a specific process under the influence of standard antimycobacterial therapy
Abstract
AIM. To study the features of phagocytic blood activity in patients with chemo-resistant pulmonary tuberculosis on a background of relapse of a specific process under the influence of standard antimycobacterial therapy.
MATERIALS AND METHODS. A study of phagocytic blood activity in 136 patients with relapse of pulmonary tuberculosis (RTB) and the first diagnosed pulmonary tuberculosis (FDPTB) was conducted, depending on the presence or absence of multi-drug resistant pulmonary tuberculosis (MDR-TB). The activity of blood phagocytosis was assessed using the phagocyte count, phagocytic index and digestion index, the spectrophotometric method.
RESULTS. In patients with pulmonary tuberculosis, violations of the activity of phagocytosis of the blood were established, namely the reduction of the above indices. After 2 months of standard anti-TB treatment, these patients did not provide a complete restoration of phagocytic blood activity. There was a significant difference between phagocytosis indices between patients with MDR-TB and susceptible TB. More pronounced inhibition of phagocytic activity of blood was observed in patients with RTB than FDPTB, regardless of the presence or absence of multi-drug resistance to anti-TB drugs.
CONCLUSIONS. Significant decrease in the activity of phagocytosis in a multi-drug resistant relapse of pulmonary tuberculosis than susceptible TB.
References
Isakova Zh.T. et al. Cartographic modeling of the prevalence of rifampicin-resistant M. tuberculosis strains in different regions of the Kyrgyz Republic. Problems of tuberculosis and lung disease. 2007. Vol. 7. P. 33-36.
WHO. Guidelines for surveillance of drug resistance in tuberculosis. Jeneva: WHO. 2009. P 83.
WHO. Anti-Tuberculosis Drug Resistance in The World: report № 4. Geneva. 2008. P 151.
Melnik VM, Novozhilova IO, Matusevich VG. Condition and shortcomings of the organization of detection of patients with chemoresistant tuberculosis. Ukrainian Pulmonology Journal. 2013.Vol. 2. P. 15–19.
Caminero J.A. Multidrug-resistant tuberculosis: epidemiology, risk factors and case finding. The internatonal Journal of Tuberculosis and Lung Disease. 2010. Vol. 14 (4). P 382-390.
Melnik VM, Novozhilova IO, Matusevich VG. An analytical look at the problem of chemoresistant tuberculosis: current status, achievements and some unresolved issues. Ukrainian Pulmonology Journal. 2012.Vol. 1. P. 5-7.
Litvinov V.I., Nikonenko B.V., Gergert V.Ya. et al. Immunology of tuberculosis: current state of the problem. Bulletin of the Russian Academy of Medical Sciences. 1999. Vol. 7. P.8-11.
Novitsky V.V., Lukyanova T.A., Strelis A.K. et al. Functional activity of phagocytic blood cells in pulmonary tuberculosis. Journal of Microbiology, Epidemiology and Immunobiology. 2006. Vol. 1. P.79-81.
Erokhin V.V., Lepekha L.N., Lovacheva O.V. and other. Features of the macrophage formula of bronchoalveolar lavage in patients with destructive pulmonary tuberculosis. Problems of tuberculosis and lung disease. 2003. Vol. 12. P.17-21.
Pasteur E.U., Gadfly V.V. and other. Immunology: Workshop. K.: Vishcha school. 1989.P. 304.
Titsa N.U. Clinical evaluation of laboratory tests. Per. from English. M.: Medicine. 1986.P. 480.
Lapach S.N., Chubenko A.V., Babich P.N. Statistical methods in biomedical research using Excel. K.: Morion 2000.P. 320.
This work is licensed under a Creative Commons Attribution 4.0 International License.
ISSN 
ISSN 
