Dynamics of Carbohydrate Metabolism Indices during the Treatment of Pulmonary Tuberculosis Patients with the Use оf Pathogenetic Therapy


Objective. To assess the dynamics of carbohydrate metabolism indices during the treatment of pulmonary tuberculosis patients with the use of pathogenetic therapy

Materials and methods. We examined 40 patients with newly diagnosed destructive pulmonary tuberculosis with bilateral infiltrative changes and massive mycobacteria excretion. Exclusion criteria were: HIV infection/AIDS, diabetes mellitus, chronic hepatitis, extrapulmonary tuberculosis and pulmonary tuberculosis without destruction and without bacterial excretion. Standardized four-component anti-TB treatment regimen was prescribed to all patients. The subjects were randomly distributed between two groups of 20 people. The treatment regimen for patients of group 2 was supplemented with a 10-day course of intravenous infusion of xylitol with a volume of 400 ml once a day. An oral glucose tolerance test (OGTT) was performed, fasting insulin levels were determined, the insulin resistance index (HOMA-IR) and body mass index (BMI) were calculated, and clinical manifestations of intoxication were evaluated. For statistical data processing, the Statistica for Windows version 13.2 generalpurpose data processing software package was used.

Results and discussion. At the beginning of treatment, patients of both groups had complaints typical for intoxication syndrome and signs of carbohydrate metabolism disorders in the form of the development of insulin resistance. The median value of the HOMA-IR index in group 1 was 3.03, and in group 2 it was 3.36. During the treatment, in group 2, whose patients received xylitol, a decrease in the average term of relief of intoxication symptoms was observed compared with group 1 (7±2 days vs 11±3 days) (p<0.05). In group 2 the median of insulin level decreased at a statistically significant level (p<0.05) (from 16.5 mcU/mL to 11.4 mcU/mL), and the insulin resistance index HOMA-IR decreased from 3.36 to 2.0, which allows us to suppose the positive effect of xylitol on the carbohydrate metabolism of patients with infiltrative pulmonary tuberculosis with destructive changes and mycobacteria excretion.

Conclusions. Based on the obtained data, it can be concluded that xylitol has a positive modeling effect on the dynamics of carbohydrate metabolism in patients with destructive pulmonary tuberculosis with bacterial excretion.

Keywords: pulmonary tuberculosis, insulin, fasting blood glucose, HOMA-IR, xylitol.


Magee M.J., Salindri A.D., Kyaw N.T., Auld S.C., Haw J.S., Umpierrez G.E. Stress Hyperglycemia in Patients with Tuberculosis Disease: Epidemiology and Clinical Implications. Curr Diab Rep. 2018; 18 (9): 71.

Courses S.V., Nikonov V.V. Stress hyperglycemia: discussion of ways to eliminate it using polyhydric alcohols. Medicine of non-emergency stanіv. 2019; 4 (99): 30-37.

Apostilidou I., Prielipp R.C. Perioperative Hyperglycemia Raises Risks Inflammation/Hormones Increase Adverse Outcomes. Newsletter (the Official Journal of the Anesthesia Patient Safety Foundation). 2006; 21 (1): 21-40.

Packer M. Activation and Inhibition of Sodium-Hydrogen Exchanger Is a Mechanism That Links the Pathophysiology and Treatment of Diabetes Mellitus With That of Heart Failure. Circulation. 2017 Oct 17; 136 (16): 1548-1559.

Jafar N., Edriss H., Nugent K. The Effect of Short-Term Hyperglycemia on the Innate Immune System. Am J Med Sci. 2016 Feb; 351 (2): 201-211.

Order of the Ministry of Health of Ukraine dated 21.12.2012 № 1118 "On approval and implementation of medical and technological documents for standardization of medical care for type 2 diabetes". Adapted evidence-based clinical guideline. Kiev; 2012. 316 p.

Global IDF/ISPAD Guideline for Diabetes in Childhood and Adolescence. International Diabetes Federation. 2011: 131.

American Diabetes Association: Standards of Medical Care in Diabetes 2017. Diabetes Care. 2017; 40 (1): 1-135. doi: 10.2337/dc17-S001.

Feshchenko YI, Todoriko LD, Kuzhko MM, Gumeniuk MI. Pathomorphosis of tuberculosis - the realities of today, chemoresistance as a sign of progression. Ukr. pulmonol. J. 2018; 2: 6-10.

Todoriko LD, Semianiv IO, Slyvka VI, Vakaryuk MM, Sulyatytska Zh.V. Diabetes mellitus and tuberculosis: the problem of syntropy of comorbid pathology. Int. J Endocrin. 2018; 14 (4): 392-394.

How to Cite
Shvets, O., & Shevchenko, O. (2019). Dynamics of Carbohydrate Metabolism Indices during the Treatment of Pulmonary Tuberculosis Patients with the Use оf Pathogenetic Therapy. Infusion & Chemotherapy, (2), 21-25. https://doi.org/10.32902/2663-0338-2019-2-21-25

Author Biographies

O.M. Shvets, Kharkiv National Medical University, Kharkiv, Ukraine

Shvets Olha Mykolaivna
Graduate student of the Department of phthisiology and pulmonology
4 Avenue of Science, Kharkiv 61022, Ukraine

O.S. Shevchenko, Kharkiv National Medical University, Kharkiv, Ukraine

Shevchenko Olha Stanislavivna
Head of the Department of phthisiology and pulmonology
MD, professor.
4 Avenue of Science, Kharkiv, 61022, Ukraine
E-mail: diva5002007@yahoo.com